Originally Posted by
CA Jack
Always remember that just "using antibiotics" is a gamble. Generally, if you have decent knowledge of which antibiotics do what, you can make the right choices and be okay. That said, 99% chance cephalexin will just work on a flesh infection. It is the vet's #1 choice for most flesh wounds. Notice I said "most" ... but cephalexin will not handle all flesh-bacteria. If cephalexin doesn't work, then I would get a culture on the dog's leg and identify the problem exactly before doing anything else and taking another guess.
I had a case once I handled, where (unbeknownst to me) a dog had 2 different, extremely tough bacteria to deal with (Enterococcus faecium and Pseudomonas fluorescens). I tried everything, up to and including Baytril, and nothing worked. I even took her to a vet, put her in IV therapy, and she lost both her paws and I put her down.
The dog she got into a wreck with, Super Red, also had damage on her muzzle that just wouldn't go away. I did a culture on her, and it turned out that she had TWO tough bacteria: Enterococcus faecium and Pseudomonas fluorescens. No "one" antibiotic would possibly work for both of these pathogens, and because I had kept "switching antibiotics" she too had developed a super-infection that it took a year to resolve. I finally just let nature take its course, and she finally beat it on her own, but the other dog lost her life to the infection. Had I got a culture originally, and properly-identified the problem, I could have used Orbax and Clavamox together.
I realize this was a 1-in-1000 chance of happening, but that said, if your initial use of antibiotics doesn't work, then BEST PRACTICE is to get a culture on the problem and identify it exactly, so you know exactly which antibiotics you should use.
Jack