Prednisone and prednisolone are different drugs ...Originally Posted by evolutionkennels
Prednisone and prednisolone are different drugs ...
Thanks in advance Taso
From what I understand, dex is better with anti-inflammation (30x better than hydrocortisone); solu-delta is better for straight shock.
Solu medrol is good at both ...
For anti-inflammation i use dex for sure. I just want to have the best available anti shock for dogs in my kit, in case i need it. Solu delta cortef has been helpful to me before.
Solu medrol has Methylprednisolone as active ingredient. But i can't find much sites that has "shock" it in the list of indications with real studies to back that up.
http://www.rxmed.com/b.main/b2.pharm...LU-MEDROL.htmlShock: In severe hemorrhagic or traumatic shock adjunctive use of i.v. methylprednisolone may aid in achieving hemodynamic restoration. (Although there are no well-controlled [double-blind placebo] clinical trials, data from experimental animal models indicate that methylprednisolone may be useful in hemorrhagic and traumatic shock. See also Warnings regarding septic shock.) Corticoid therapy should not replace standard methods of combating shock, but present evidence indicates that concurrent use of large doses of corticoids with other measure may improve survival rates.
http://dailymed.nlm.nih.gov/dailymed...f-3e3795c70032A study has failed to establish the efficacy of SOLU-MEDROL in the treatment of sepsis syndrome and septic shock. The study also suggests that treatment of these conditions with SOLU-MEDROL may increase the risk of mortality in certain patients (i.e., patients with elevated serum creatinine levels or patients who develop secondary infections after SOLU-MEDROL).
First of all, they're not much different from each other:
Solu-Delta = Prednisolone sodium succinate
Solu-Medrol = methylPrednisolone sodium succinate
Secondly, septic shock is different from hypovolemic/trauma shock.
Finally, I guess the best evidence I have found regarding the use of Solu-Medrol is the fact it is used in trauma hospitals worldwide.
Jack
Hell, in just a brief search, here is evidence that even Solu-Delta doesn't help anywhere near as much as just lactated ringers alone for massive blood loss ...
"The addition of prednisolone sodium succinate to the treatment regimen improved the effectiveness of LRS alone only in some dogs at random sampling times. Significant trends were not observed except, possibly, the improvement of venous pH and A-V pH and PCO2 differences".
Thanks Jack. I have (re)found(lol) your article about solu medrol also, good stuff its all in there.
Since you say its good for both anti-inflammation and shock, would/should you leave the dex out when you need the solu medrol anyway?
Lactated ringers i have. Is shock in/after a show mostly caused by massive blood loss? I never thought about the cause..
No, dex is great for (say) if the leg got brutally mangled. Lotsa swelling, but no real shock to the dog. In this case, dex is the choice for reducing the swelling.
Dex is also the preferred choice for snakebites, bad spider bites (brown recluse, etc.).
The good thing about Solu-Delta is it is very fast-acting, but it also is out of the dog very fast, so it's a double-edged sword.
Solu-Medrol stays in the dog longer than Solu-Delta, which can be important if you don't have a lot onhand.
The elements that cause shock in a dog deal are: 1) blood loss/dehydration, 2) trauma/swelling, 3) absolute total exhaustion, and 4) pain.
Jack
Thanks
Jack, i have this ones also.
http://www.drugs.com/pro/voluven.html
Is it better then standard lactated ringers for shock in case of blood loss?
Unfortunately, I have no experience with Voluven.
I do know that hypertonic saline is another valuable aid to shock recovery though ...
Jack
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